Goal-directed Fluid Resuscitation in Acute Pancreatitis
- Conditions
- Acute Pancreatitis
- Interventions
- Other: Goal-directed fluid resuscitation
- Registration Number
- NCT00853515
- Lead Sponsor
- Brigham and Women's Hospital
- Brief Summary
Vigorous fluid resuscitation is currently believed to play a key role in reducing complications associated with acute pancreatitis. However, aggressive fluid replacement can be associated with complications such as pulmonary fluid sequestration. The purpose of this study is to evaluate alternative approaches to early fluid resuscitation for patients with acute pancreatitis.
- Detailed Description
Primary Aim: Evaluate the impact of a goal-directed fluid resuscitation protocol compared to standard fluid resuscitation on systemic inflammation in patients with acute pancreatitis.
Secondary Aim: Evaluate the impact of resuscitation with Lactated Ringer's compared to normal saline on systemic inflammation in acute pancreatitis.
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 40
- acute pancreatitis diagnosed by at least 2 criteria
- adult patients at least 18 years of age
- history of severe cardiovascular, respiratory, renal, hepatic or hematologic/immunologic disease
- concurrent metabolic or physiologic derangement requiring specific fluid management
- pregnancy
- patients transferred from acute care hospital
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 1 Goal-directed fluid resuscitation Goal-directed fluid resuscitation with lactated Ringer's solution 2 Goal-directed fluid resuscitation Goal-directed fluid resuscitation with normal saline
- Primary Outcome Measures
Name Time Method Prevalence (point prevalence) of the systemic inflammatory response syndrome (SIRS) at 24 hours first 24 hours of hospitalization
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Brigham and Women's Hospital
🇺🇸Boston, Massachusetts, United States