Oral Probiotics vs Standard Antibiotic Therapy for Bacterial Vaginosis- A Randomised, Double Blind, Clinical Study

Bacterial Vaginosis is a polymicrobial syndrome where the lactobacilli-dominated vaginal microflora is replaced by a mix of other, mainly anaerobic bacteria species. Renewed attention has recently been focused on approaches involving alternative ‘natural’ treatments that could be effective in the microbiological and clinical resolution of the condition without side effects. A meta-analysis involving 10 RCTs with a low or moderate risk of bias, suggested that the treatment with probiotics alone was more effective in the therapy of Bacterial Vaginosis for both short- and long-term; however, the probiotics used after antibiotic treatment was effective only for a short term

Thus, probiotics rather than antibiotics have promising results in reducing the recurrence rate of bacterial vaginosis

Thus, the aim of the study is ’to compare the efficacy of standard therapy vs oral probiotics in women with bacterial vaginosis’

100 women with bacterial vaginosis will be randomised into 2 equal groups and each group will be given either oral probiotics or Metronidazole(standard treatment) and assessed after 30 days to see for recurrence of bacterial vaginosis.

Hypothesis: Probiotics confer long term benefit for treatment of Bacterial Vaginosis as compared to Standard Antibiotics.