Milk Polar Lipids Consumption, Lipid Metabolism, and Inflammation in Menopausal Women
- Conditions
- Cardiometabolic Risk
- Interventions
- Other: 3g milk polar lipid fortified cheese consumptionOther: 5g milk polar lipid fortified cheese consumptionOther: Unfortified cheese product consumption
- Registration Number
- NCT02099032
- Lead Sponsor
- Hospices Civils de Lyon
- Brief Summary
Polar lipids have a specific chemical structure: they are an essential component of human cell membranes, play a major role in the nervous system and also influence the metabolic pathways including the cholesterol metabolism.
Polar lipids are used in food-processing industry for their emulsification properties. The most famous emulsifier is soya lecithin but milk also naturally contains natural emulsifiers such as polar lipids.
The purpose of this research is to study plasma cholesterol variation after daily intake of milk polar lipids-fortified cheese products. The volunteers will have to consume 100 g of cheese product during four weeks instead of their usual cheese products.
It is a bi-centric study with a centre in LYON (Centre de Recherche en Nutrition Humaine Rhône-Alpes) and CLERMONT-FERRAND (Centre de Recherche en Nutrition Humaine Auvergne).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 59
- Menopausal women
- Of less than 75 years old- Body Mass Index of 25 to 35 kg/m2
- Waist circumference greater than 80 cm
- Normal (or not clinically significant) glycemic and lipid parameters
- Dairy products allergy or intolerance
- Smokers (more than five cigarettes/day)
- HDL cholesterol greater than 1.5 mmol/L
- Medication that could interfere with lipid metabolism or intestinal microbiota (for example, no antibiotics within the 2 months before the study)
- Hormone replacement treatment for menopause
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 3g milk polar lipid fortified cheese product 3g milk polar lipid fortified cheese consumption Women will have to consume daily 100g of a cheese product instead of usual cheese products during four weeks. 5 g milk polar lipid fortified cheese product 5g milk polar lipid fortified cheese consumption Women will have to consume daily 100g of a cheese product instead of usual cheese products during four weeks. Unfortified cheese product Unfortified cheese product consumption Women will have to consume daily 100g of a cheese product instead of usual cheese products during four weeks
- Primary Outcome Measures
Name Time Method Total plasma cholesterol Day 0 and Day 28 Total plasma cholesterol will be measured fasting before and after the four weeks of cheese product intake.
- Secondary Outcome Measures
Name Time Method Body composition measurement with bioimpedancemetry Day 0 and Day 28 Body composition will be measured fasting before and after the four weeks of cheese product intake.
Energy expenditure and substrate oxidation with indirect calorimetry Day 0 and Day 28 Energy metabolism will be measured before and after the four weeks of cheese product intake. Fasting and during all the postprandial period (480 minutes)
Plasma lipids Day 0 and Day 28 Plasma lipids will be measured before and after the four weeks of cheese product intake. Fasting and postprandial measurements over 8 hours depending on parameters (time 60-120-180-240-270-300-360-420-480 minutes)
Plasma glucose and insulin Day 0 and Day 28 Plasma glucose and insulin will be measured before and after the four weeks of cheese product intake. Fasting and postprandial measurements over 8 hours.
Intestinal microbiota with molecular approach before and after the four weeks of cheese product intake Stools will be collected at home before and after the four weeks of cheese product intake.
Inflammatory markers Day 0 and Day 28 Inflammatory markers will be measured before and after the four weeks of cheese product intake. Fasting and postprandial measurements over 8 hours depending on parameters
Trial Locations
- Locations (2)
Centre de Recherche en Nutrition Humaine Rhône-Alpes
🇫🇷Pierre-Bénite, France
Université d'Auvergne-Laboratoire de Nutrition Humaine
🇫🇷Clermont-Ferrand, France