Towards Better Detection of Acute Sarcopenia in Hospitalized Older Adults: Integrating Clinical and Ultrasound Approaches
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 280
- 主要终点
- ACUTE SARCOPENIA INCIDENCE
研究概览
简要总结
Acute sarcopenia is a rapid decline in muscle mass and function occurring within 28 days of a major stressor, such as hospitalization, infection, or surgery. It is frequent but often underdiagnosed in older adult. Current standard of care lacks systematic strategies for its early detection and risk stratification. This study therefore proposes to combine established clinical and instrumental assessments (handgrip dynamometry, bioelectrical impedance analysis, ultrasound of the anterior thigh) to better characterize the risk factors, and outcomes of acute sarcopenia in hospitalized patients aged 65 years or older.
The study hypothesis is that the use of a systematic objective clinical assessments will improve early detection and risk stratification of this condition and the detection of acute sarcopenia related outcomes.
This is a prospective observational cohort study that will be conducted in the Emergency Department and Medical Wards of the San Raffaele Hospital.
Studies objectives will include:
- Determination of the incidence of acute sarcopenia
- Identification of clinical and demographic risk factors for acute sarcopenia and relevant clinical outcomes associated with this condition
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged 65 years or older.
- •Hospital admission for an acute medical condition
排除标准
- •Presence of pre-existing neuromuscular disorders.
- •Diagnosis of terminal illness with life expectancy less than 30 days
- •Refuse to sign written informed consent
研究组 & 干预措施
Groups: older adults aged 65 years or above, hospitalized for acute medical condition
Groups: older adults (male and female) aged 65 years or above, hospitalized for acute medical conditions.
干预措施: Acute sarcopenia will be defined as the incidence of sarcopenia compared to baseline measurements at recruitment, using the European Working Group on Sarcopenia in older people 2 (EWGSOP2) criteria (Diagnostic Test)
结局指标
主要结局
ACUTE SARCOPENIA INCIDENCE
时间窗: Time point(s): baseline (within 24h of admission), days 3, 5, 7, 10, then every 5 days until hospital discharge (on average maximum 20 days after hospital admission).
Primary Objective: to determine the incidence of acute sarcopenia, defined as a reduction in muscle mass and strength during hospitalization in older adults. Primary Endpoint: incidence of acute sarcopenia, defined as a reduction in muscle mass (BIA and anterior thigh ultrasound) and muscle strength (handgrip dynamometry) compared with baseline.
次要结局
- ACUTE SARCOPENIA RISK FACTORS AND OUTCOMES(Time point(s): baseline (within 24h of admission), days 3, 5, 7, 10, every 5 days until hospital discharge (on average maximum 20 days after hospital admission), and follow-ups at 3 and 6 months.)
研究者
Sarah Damanti
Principal Investigator
IRCCS San Raffaele