Comparison of Aqueous and Plasma Glucose Level in Diabetic Patients
试验速览
- 阶段
- 不适用
- 入组人数
- 25
- 主要终点
- Aqueous humor glucose concentration
研究概览
简要总结
Comparison of aqueous and plasma glucose level in diabetic patients
High glucose concentrations in aqueous humor are thought to be related of diabetic ocular injury, including cataract and diabetic keratopathy. The primary mechanisms are nonenzymatic glycation, oxidative stress and activation of polyol pathway. However, glucose concentrations in aqueous humor of diabetic patients was only examined in a few patients in the past.
This study will compare glucose concentration in blood plasma and aqueous humor in diabetic patients undergoing cataract surgery. Perioperative Hemoglobin A1c concentrations will also be examined. Correlation between these parameters will be analyzed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diabetic patients planed for elective cataract surgery
排除标准
- •s/p traumatic eye injury
- •past or current uveitis
- •patients using prescription eye drops except lubricants
结局指标
主要结局
Aqueous humor glucose concentration
时间窗: Day of cataract surgery
次要结局
- Hemoglobin A1c(Perioperative month)
- Plasma glucose concentrations(Day of cataract surgery)
研究者
Prof. Irina Barequet
Cornea and refractive surgery specialist
Sheba Medical Center