Comparison of the effect of letrozole initiation on ovulation on the cycle day 3 with cycle day 5 in polycystic ovary syndrom patients
Phase 2
- Conditions
- Polycystic ovarian syndrome.Polycystic ovarian syndrome
- Registration Number
- IRCT201307096467N3
- Lead Sponsor
- Vice Chancellor for Research of Mashhad University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 70
Inclusion Criteria
The main inclusion criteria to study: women with previously diagnosed polycystic ovary syndrome (PCOS) and infertility according to ?Rotterdam criteria; Age between 20-30 years; No previous history of ovarian surgery; Women ?who did not ovulate on clomiphene citrate in at least 3 previous cycles (did not attain at least 1 ?follicle equal or more than 18mm on ultrasound scan). The main exclusion criteria from study: Women with infertility of any ?other etiology; Exposure to cytotoxic drugs; Pelvic radiation therapy?
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Follicle equal or more than 18mm. Timepoint: Before the first dose of letrozole? and 3 days after the last dose of letrozole dose. Method of measurement: Vaginal ultrasonography.;Endometrial thickness ?. Timepoint: Before the first dose of letrozole? and 3 days after the last dose of letrozole dose. Method of measurement: Vaginal ultrasonography.;Testosterone Hormone. Timepoint: Before the first dose of letrozole? and 3 days after the last dose of letrozole dose. Method of measurement: Blood test.;Androstendione Hormone. Timepoint: Before the first dose of letrozole? and 3 days after the last dose of letrozole dose. Method of measurement: Blood test.;Estradiol Hormone. Timepoint: Before the first dose of letrozole? and 3 days after the last dose of letrozole dose. Method of measurement: Blood test.
- Secondary Outcome Measures
Name Time Method Pregnancy. Timepoint: At the end of Menstrual cycle. Method of measurement: BHCG test.