Diagnostic of Iron Deficiency by Means of Non Invasive Measurement of Zink Protoporphyrin IX
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Validation of the non-invasive ZincProtoporphyrinIX measurement
研究概览
简要总结
ZnPP is being build in the case of a functional iron deficiency. Zinc instead of iron is implemented into protoporphyrin IX. This ZincProtoporphyrin (ZnPP) can be detected non invasively. Non invasive and invasive optical measurement of ZnPP will be compared. Additionally ZnPP measurements will be compared to other iron deficiency parameters for validation by the investigators.
详细描述
Zinc-protoporphyrin (ZnPP) will be measured by a fluorescence technique. Restricted wave light (407/425 nm) is used to detect ZnPP in the bloodstream non-invasively through the oral mucosa. The spectroscopic measurements are translated into a ZnPP value (mumol/mol heme).
The non-invasive measurement of ZnPP is validated and compared to optical measurement of ZnPP in whole blood and high performance liquid chromatography (HPLC) measurement of ZnPP in whole blood.
The ZnPP value is compared to other iron-deficiency parameters: Ferritin, Transferrin saturation and soluble Transferrin receptor.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients seen preoperatively in the Anesthestic clinic
- •Patients > 18 years of age
- •Understood and signed patient consent
排除标准
- •transfusion of blood products 8 weeks prior to screening
- •Pregnancy
- •Porphyria
结局指标
主要结局
Validation of the non-invasive ZincProtoporphyrinIX measurement
时间窗: Baseline
The value is compared to optical measurement of ZincProtoporphyrin in whole blood; in addition the value is compared to HPLC measurement in whole blood
次要结局
- Comparison of the ZincProtoporyphyrinIX value to other iron-deficiency parameters(Baseline)
研究者
Philipp Stein
Dr. med Philipp Stein
University of Zurich