The predictive value of PET-CT and PET-DW-MRI early during chemoradiotherapy for head and neck cancer

Recruiting

• Registration Number: NL-OMON28050
• Lead Sponsor: Prof. dr. R. de BreeDepartment of Otolaryngology/ Head and Neck surgeryVU University Medical Center1081 HV Amsterdam+31204443689+31204443688r.bree@vumc.nl

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

Squamous cell carcinoma

-Oral cavity, pharynx or larynx

Exclusion Criteria

-Age < 18 years

-Pregnancy

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To investigate the diagnostic value of FDG-PET-CT and DW-MRI (EPI and non-EPI technique) applied 2 weeks after the start of primary chemoradiotherapy for HNSCC to predict locoregional response in the primary tumor and cervical node metastases.

Secondary Outcome Measures

Name	Time	Method
To determine the value of different criteria, related to the primary objective, such as:<br /><br>•FDG uptake level pretreatment (on PET-CT and PET-MRI)<br /><br>•Residual FDG uptake level after 14 days of therapy (on PET-CT and PET-MRI)<br /><br>•Change of FDG uptake (on PET-CT and PET-MRI)<br /><br>•b=1000 signal intensity and ADC level pretreatment (for both EPI- and non-EPI-technique)<br /><br>•Residual b=1000 signal intensity and ADC level after 14 days of therapy (for both EPI- and non-EPI-technique)<br /><br>•Change of b=1000 signal intensity and ADC (for both EPI- and non-EPI-technique)<br>FDG-uptake levels obtained from PET-CT and PET-MRI will be compared (taking into account the different time intervals between FDG-injection and scanning)