NL-OMON22670已完成不适用
Observational study. <br>Measurements of pulmonary function in children aged 0 – 4 years: children with CF and healthy controls.
H.A.W.M. Tiddens, M.D., PhD.and ms. E.M. Bakker, M.D.0 个研究点目标入组 45 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 45
研究概览
简要总结
- Kerem, B., et al., Identification of the cystic fibrosis gene: genetic analysis. Science, 1989. 245(4922): p. 1073-80.
2. Armstrong, D.S., et al., Lower respiratory infection and inflammation in infants with newly diagnosed cystic fibrosis. Bmj, 1995. 310(6994): p. 1571-2.
3. Nixon, G.M., et al., Early airway infection, inflammation, and lung function in cystic fibrosis. Arch Dis Child, 2002. 87(4): p. 306-11.
4. Armstrong, D.S., et al., Lower airway inflammation in infants and young children with cystic fibrosis. Am J Respir Crit Care Med, 1997. 156(4 Pt 1): p. 1197-204.
5. Dakin, C.J., et al., Inflammation, infection, and pulmonary function in infants and young children with cystic fibrosis. Am J Respir Crit Care Med, 2002. 165(7): p. 904-10.
6. Gappa, M., S.C. Ranganathan, and J. Stocks, Lung function testing in infants with cystic fibrosis: lessons from the past and future directions. Pediatr Pulmonol, 2001. 32(3): p. 228-45.
7. Stromberg, N.O. and P.M. Gustafsson, Ventilation inhomogeneity assessed by nitrogen washout and ventilation-perfusion mismatch by capnography in stable and induced airway obstruction. Pediatr Pulmonol, 2000. 29(2): p. 94-102.
8. Schibler, A., et al., Moment ratio analysis of multiple breath nitrogen washout in infants with lung disease. Eur Respir J, 2000. 15(6): p. 1094-101.
9. Kraemer, R., et al., Ventilation inhomogeneities in relation to standard lung function in patients with cystic fibrosis. Am J Respir Crit Care Med, 2005. 171(4): p. 371-8.
10. Aurora, P., et al., Multiple breath inert gas washout as a measure of ventilation distribution in children with cystic fibrosis. Thorax, 2004. 59(12): p. 1068-73.
11. Fuchs, S.I., et al., Multiple breath washout with a sidestream ultrasonic flow sensor and mass spectrometry: A comparative study. Pediatr Pulmonol, 2006. 41(12): p. 1218-25.
12. Gustafsson, P.M., Inert gas washout in preschool children. Paediatr Respir Rev, 2005. 6(4): p. 239-45.
13. Tiddens, H.A., Detecting early structural lung damage in cystic fibrosis. Pediatr Pulmonol, 2002. 34(3): p. 228-31.
14. Gustafsson, P.M., P. Aurora, and A. Lindblad, Evaluation of ventilation maldistribution as an early indicator of lung disease in children with cystic fibrosis. Eur Respir J, 2003. 22(6): p. 972-9.
15. Aurora, P., et al., Multiple-breath washout as a marker of lung disease in preschool children with cystic fibrosis. Am J Respir Crit Care Med, 2005. 171(3): p. 249-56.
16. Bush, A. and J. Davies, Early detection of lung disease in preschool children with cystic fibrosis. Curr Opin Pulm Med, 2005. 11(6): p. 534-8.
17. Urschitz, M.S., et al., Reference values for nocturnal home pulse oximetry during sleep in primary school children. Chest, 2003. 123(1): p. 96-101.
18. Gozal, D., Sleep-disordered breathing and school performance in children. Pediatrics, 1998. 102(3 Pt 1): p. 616-20.
19. Beresford, M.W., H. Parry, and N.J. Shaw, Twelve-month prospective study of oxygen saturation measurements among term and preterm infants. J Perinatol, 2005. 25(1): p. 30-2.
20. Frangolias, D.D. and P.G. Wilcox, Predictability of oxygen desaturation during sleep in patients with cystic fibrosis : clinical, spirometric, and exercise parameters. Chest, 2001. 119(2): p. 434-41.
21. Bradley, S., et al., Hypoxemia and hypercapnia during exercise and sleep in patients with cystic fibrosis. Chest, 1999. 116(3): p. 647-54.
22. Berge, M.T., et al., DNase in stable cystic fibrosis infants: a pilot study. J Cyst Fibros, 2003. 2(4): p. 183-8.
23. Chang, A.B., The physiology of cough. Paediatr Respir Rev, 2006. 7(1): p. 2-8.
24. Chang, A.B., et al., Cough quality in children: a comparison of subjective vs. bronchoscopic findings. Respir Res, 2005. 6(1): p. 3.
25. de Jongste, J.C. and M.D. Shields, Cough . 2: Chronic cough in children. Thorax, 2003. 58(11): p. 998-1003.
26. Archer, L.N. and H. Simpson, Night cough counts and diary card scores in asthma. Arch Dis Child, 1985. 60(5): p. 473-4.
27. Falconer, A., C. Oldman, and P. Helms, Poor agreement between reported and recorded nocturnal cough in asthma. Pediatr Pulmonol, 1993. 15(4): p. 209-11.
28. Chang, A.B., et al., Subjective scoring of cough in children: parent-completed vs child-completed diary cards vs an objective method. Eur Respir J, 1998. 11(2): p. 462-6.
29. Urschitz, M.S., et al., Nocturnal arterial oxygen saturation and academic performance in a community sample of children. Pediatrics, 2005. 115(2): p. e204-9.
研究设计
- 研究类型
- Observational
入排标准
入选标准
- •Inclusion criteria for children with CF:
- •1. Age 0 – 4 years (0 up to and including 4 years);
排除标准
- •Exclusion criteria for children with CF:
- •1. Medical conditions that might affect the measurements (e.g. cardiac problems that can influence saturation);
研究者
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