Endothelial Function, Arterial Stiffness and Components of Metabolic Syndrome in Acute Lymphoblastic Leukemia (ALL) Survivors

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins2 sites in 1 country32 target enrollmentJune 2011

ConditionsAcute Lymphoblastic Leukemia

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Acute Lymphoblastic Leukemia
Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Enrollment: 32
Locations: 2
Primary Endpoint: measure of endothelial
Status: Completed
Last Updated: 13 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Specific Aim: Compare the endothelial function, arterial stiffness and components of metabolic syndrome of childhood Acute Lymphoblastic Leukemia (ALL) survivors to healthy sibling controls. Plan: A cross sectional study comparing ALL survivors to sibling controls including measures of endothelial function and arterial stiffness obtained form a peripheral artery tonometry device, height, weight, waist circumference, fasting lipid, glucose and insulin.

Registry

clinicaltrials.gov

Start Date

June 2011

End Date

February 2013

Last Updated

13 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Ages 8-28 (8 is chosen as lower age limit because developmental understanding will allow survivor to follow instructions for procedures, 28 is chosen as upper limit to include age ranges seen for treatment in the pediatric program)
•Off therapy for at least 6 months and not more than 10 years (6 months
•Biological sibling
•Ages 8-28 (when more than one sibling is available the one closest in age will be chosen.))

Exclusion Criteria

•Uncontrolled medical conditions that could interfere with participation or interpretation of results
•History of relapsed ALL or history of bone marrow transplantation