Muscle Evaluation Using Ultrasound in the Critically Ill : ULTRAMUSCLE Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Critical Illness
- Sponsor
- University Hospital, Montpellier
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Ultrasound characteristics of the quadriceps
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
Critical illness is associated with ICU acquired weakness and diaphragmatic dysfunction.
Ultrasound can evaluate the muscle mass non invasively and provides the ability for a muscle follow up during and after the ICU stay. Magnetic stimulation of the phrenic nerves and the measure of the end expiratory tracheal pressure with an occlusion valve allows to evaluate the diaphragm force production in mechanically ventilated patients.
The aim of the present study is to constitute an image bank and to describe the muscle mass and function recovery in critically ill patients.
Detailed Description
Critical illness is associated with ICU acquired weakness and diaphragmatic dysfunction. Ultrasound can evaluate the muscle mass non invasively and provides the ability for a muscle follow up during and after the ICU stay. Magnetic stimulation of the phrenic nerves and the measure of the end expiratory tracheal pressure with an occlusion valve allows to evaluate the diaphragm force production in mechanically ventilated patients. The aim of the present study is to constitute an image bank and to describe the mass and function recovery in critically ill patients. Ultrasound and clinical data will be collected and analysed during the ICU stay.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Critically ill patients with at least one organ failure defined, organ failure being defined by a SOFA equal or above 3 for the organ, and an expected duration of ICU stay equal of above 3 days
- •Exclusion criteria:
- •Pregnancy, age below 18, absence of consent
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Ultrasound characteristics of the quadriceps
Time Frame: Since admission at day 0 and measured repetitively by 48 hours untildischarge from ICU or date of death from any cause, whichever came first, assessed up to day 28
Changes in ultrasound characteristics of the quadriceps : cross sectional area of quadriceps (cm2)