The MPAC-study: validating craniocaudal tumor extension on MRI with histoPAthology in patients with Cervical cancer

Completed

• Conditions: cervical cancer; uterine cervical carcinoma; 10038594

• Registration Number: NL-OMON43285
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Trial is onging in other countries

Detailed Description

Not available

Study Timeline

• Study Completion: 2017-01-24
• Results First Posted: 2018-08-28
• Last Update Posted: 2024-04-15

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 41

Inclusion Criteria

Patients with a carcinoma of the cervix for whom a Wertheim surgical procedure is planned. They must be older than 18 years of age and have a WHO status of 0 or 1.

Exclusion Criteria

Exclusioncirteria are MRI related. Patients with claustrophobia, a pacemaker, medicine pump, neurostimulator, cochlear implants, other metal implants in the pelvis wich would disturb the image. In some cases surgical clips in the brain are contra-indicated, this will be evaluated conform standard protocol. Patients with a GFR < 30 ml/min/1,73 m² wil be excluded.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Craniocaudal primary tumor extension in direction of the uterine fundus on T2<br /><br>weighted 3T MRI enforced with DWI/DCE compared to histopathology. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>To establish the correlation of T2 weighted MRI enforced with DCE and DWI with<br /><br>the microscopic tumor extent in uterine cervical cancer in uterus and<br /><br>parametrium.</p><br>