Canderel:Effects on Blood Glucose Concentration and Appetite Scores

Not Applicable

• Conditions: Appetitive Behavior; Glucose Metabolism Disorders
• Interventions: Dietary Supplement: Canderel drink; Dietary Supplement: Canderel+Lyle's Golden Syrup drink

• Registration Number: NCT03232008
• Lead Sponsor: King's College London

Brief Summary

This study investigates the effects of Canderel, an aspartame and acesulfame-k blend artificial sweetener powder, on post-postprandial blood glucose levels and appetite scores.

Detailed Description

The study is separated into two parts: A) investigating the effects of artificial sweeteners in combination with complex carbohydrates; and B) investigating the effects of artificial sweeteners in combination with simple sugars.

A) Participants will be randomly given either the placebo drink (3g of maltodextrin dissolved in 250ml of water) or the Canderel drink (3g of Canderel dissolved in 250ml of water) alongside an isocaloric high carbohydrate breakfast. Blood glucose measurements will be obtained through finger pricking and appetite will be measured using self-reported visual analog scores rating hunger, desire to eat, fullness and alertness for up to 3 hours after breakfast.

B)Participants will be randomly given either the placebo drink (3g of Lyle's Golden syrup and 3g of maltodextrin dissolved in 250ml of water) or the Canderel+sugars drink (3g of Canderel and 3g of Lyle's Golden syrup dissolved in 250ml of water) . Blood glucose measurements will be obtained through finger pricking and appetite will be measured using self-reported visual analog scores rating hunger, desire to eat, fullness and alertness for up to 3 hours after drink

Study Timeline

• Study Start: 2015-09-01
• Study First Submitted: 2017-06-19
• Study First Submitted QC: 2017-07-26
• Study First Posted: 2017-07-27
• Primary Completion: 2019-02-28
• Status Verified: 2020-09
• Last Update Submitted: 2020-09-21
• Last Update Posted: 2020-09-22
• Study Completion: 2021-03-28

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 110

Inclusion Criteria

• Healthy male and female adults (18-64)

Exclusion Criteria

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Experiment A- experimental	Canderel drink	3g Canderel in 250ml water
Experiment B- experimental	Canderel+Lyle's Golden Syrup drink	3g Canderel + 35g Lyle's Golden Syrup in 250 ml water

Primary Outcome Measures

Name	Time	Method
Change in Blood glucose	0-180min (Measured from baseline to 90min every 15min; 90-180min every 30min)	Capillary blood obtained from fingerprick and measured using glucose monitor
Change in Appetite	0-180min (Measured from baseline to 90min every 15min; 90-180min every 30min)	Feelings of hunger, desire to eat, fullness and alertness measured using Visual Analog Scale (VAS)

Trial Locations

Locations (1)

King's College London; 🇬🇧 London, United Kingdom