The Effects of Canderel (Aspartame and Acesulfame-k Blend) on Blood Glucose Concentration and Appetite Scores in Humans: a Randomised Controlled Trial
试验速览
- 阶段
- 不适用
- 入组人数
- 110
- 试验地点
- 1
- 主要终点
- Change in Blood glucose
研究概览
简要总结
This study investigates the effects of Canderel, an aspartame and acesulfame-k blend artificial sweetener powder, on post-postprandial blood glucose levels and appetite scores.
详细描述
The study is separated into two parts: A) investigating the effects of artificial sweeteners in combination with complex carbohydrates; and B) investigating the effects of artificial sweeteners in combination with simple sugars.
A) Participants will be randomly given either the placebo drink (3g of maltodextrin dissolved in 250ml of water) or the Canderel drink (3g of Canderel dissolved in 250ml of water) alongside an isocaloric high carbohydrate breakfast. Blood glucose measurements will be obtained through finger pricking and appetite will be measured using self-reported visual analog scores rating hunger, desire to eat, fullness and alertness for up to 3 hours after breakfast.
B)Participants will be randomly given either the placebo drink (3g of Lyle's Golden syrup and 3g of maltodextrin dissolved in 250ml of water) or the Canderel+sugars drink (3g of Canderel and 3g of Lyle's Golden syrup dissolved in 250ml of water) . Blood glucose measurements will be obtained through finger pricking and appetite will be measured using self-reported visual analog scores rating hunger, desire to eat, fullness and alertness for up to 3 hours after drink
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 64 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Healthy male and female adults (18-64)
排除标准
- 未提供
研究组 & 干预措施
Experiment A- experimental
3g Canderel in 250ml water
干预措施: Canderel drink (Dietary Supplement)
Experiment A- control
3g of maltodextrin in 250 ml of water
Experiment B- experimental
3g Canderel + 35g Lyle's Golden Syrup in 250 ml water
干预措施: Canderel+Lyle's Golden Syrup drink (Dietary Supplement)
Experiment B- control
3g Lyle's Golden Syrup + 35g of maltodextrin in 250 ml of water
结局指标
主要结局
Change in Blood glucose
时间窗: 0-180min (Measured from baseline to 90min every 15min; 90-180min every 30min)
Capillary blood obtained from fingerprick and measured using glucose monitor
Change in Appetite
时间窗: 0-180min (Measured from baseline to 90min every 15min; 90-180min every 30min)
Feelings of hunger, desire to eat, fullness and alertness measured using Visual Analog Scale (VAS)
次要结局
未报告次要终点
研究者
Dr Christopher Corpe
Nutrition Sciences Lecturer, Principal investigator
King's College London