Mortality Outcome of Controlled Hypertension in Randomized Controlled or Open-label Study Intentionally Directed Intervention Effect Blood Pressure: A Systematic Review and Meta-Analysis
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- All-cause mortality
研究概览
简要总结
Despite advances in antihypertensive therapy, some patients with well-controlled blood pressure still experience fatal outcomes. This paradox raises critical questions about the efficacy of blood pressure-targeted interventions and whether BP control alone ensures survival. This systematic review and meta-analysis aims to evaluate all-cause mortality and cardiovascular death among hypertensive patients who achieved BP targets in RCTs or open-label trials.
To determine whether achieving controlled blood pressure through intentional intervention (pharmacological or procedural) in RCTs or open-label studies reduces mortality (all-cause and cardiovascular) in hypertensive patients.
详细描述
Sensitivity Analyses Excluding high-risk of bias studies Excluding short follow-up (<1 year)
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults ≥18 years with diagnosed hypertension
- •Blood pressure controlled at target values defined by the study (e.g., <140/90 mmHg or <130/80 mmHg)
- •Any comorbidity allowed unless the study focuses on pregnancy or pediatric population
排除标准
- •Observational or retrospective studies
- •Pediatric or pregnant participants
- •Case reports, editorials, or conference abstracts without full data
- •Studies not reporting mortality outcomes separately for controlled BP
研究组 & 干预措施
Antihypertensive treatment
Participants assigned to interventions (pharmacological, device-based, or lifestyle) directed at lowering blood pressure or Antihypertensive agents, Blood pressure-lowering treatment, Antihypertensive therapy.
干预措施: Antihypertensive treatment (Drug)
Control/Comparator
Participants receiving placebo, standard of care, or no intervention
结局指标
主要结局
All-cause mortality
时间窗: 100 year
All cause mortality by controlable hypertension treatment
次要结局
未报告次要终点
研究者
Nathaphong Dejthida
Research Physician
DejthidaNathaphong