Investigating immune cells in the lungs of people with severe community-acquired pneumonia
Not Applicable
- Conditions
- Community-acquired pneumoniaRespiratory
- Registration Number
- ISRCTN19920744
- Lead Sponsor
- niversity of Oxford
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Ongoing
- Sex
- All
- Target Recruitment
- 15
Inclusion Criteria
1. Admitted to a critical care setting in the Oxford University Hospital Trust
2. Mechanically ventilated for less than 72 h
3. Diagnosis of community acquired pneumonia has been made by the treating physicians based on the following criteria:
3.1. Symptoms and/or signs consistent with a lower respiratory tract infection
3.2. Radiological evidence of new onset consolidation on a chest x-ray or CT scan
4. Aged =16 years
5. Able to consent themselves or declaration obtained from a personal or professional consultee
Exclusion Criteria
1. Previously included in the study
2. Hospital admission in the past 30 days (prior to this current presentation)
3. Long-term resident of a nursing home or other residential care facility
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Quantity and phenotype of lung-derived T-cell populations measured using flow cytometry at a single timepoint within 72 h of the establishment of mechanical ventilation
- Secondary Outcome Measures
Name Time Method Severity of respiratory failure and other organ failure using the sequential organ failure assessment (SOFA) score during the 90 days following admittance or the period from hospital admittance to discharge