Intestinal Biomarker Analysis After ECP for ICI Colitis
- Conditions
- ColitisImmune Checkpoint Inhibitor-Related Colitis
- Registration Number
- NCT06074874
- Lead Sponsor
- University of Freiburg
- Brief Summary
It was previously shown that ICI-colitis can be treated with extracorporeal photophoresis. Therefore this retrospective analysis is launched to study the chnages of immune cells in the peripheral blood and intestinal tract in an ICI colitis patient cohort. The analysis will include the evaluation of intestinal and peripheral blood biomarkers in patients with ICI colitis receiving ECP as a treatment.
- Detailed Description
It was previously shown that ICI-colitis can be treated with extracorporeal photophoresis. Therefore this retrospective analysis is launched to study the changes of immune cells in the peripheral blood and intestinal tract in an ICI colitis patient cohort. The analysis will include the evaluation of intestinal and peripheral blood biomarkers in patients with ICI colitis receiving ECP as a treatment.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
- ICI colitis
- no informed consent
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method T cell number and phenotype measurement in the intestinal tract 6 months Analysis of CD3+ T cells by flow cytometry
- Secondary Outcome Measures
Name Time Method T cell number measurement by immunohistochemistry 6 months Analysis of CD3+ T cells by immunohistochemistry
Analysis of arginase amounts in the intestinal tract using qPCR 6 months Analysis of arginase mRNA expression by realtime PCR (qRT-PCR)
Trial Locations
- Locations (1)
Freiburg University Medical Center
🇩🇪Freiburg, Baden Württemberg, Germany