Natural History of Plexiform in Neurofibromatosis Type I
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Plexiform Neurofibromas
- Sponsor
- National Cancer Institute (NCI)
- Enrollment
- 24
- Locations
- 1
- Primary Endpoint
- Monitor natural history of plexiform neurofibromas
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
Background:
-Plexiform neurofibromas in patients with NF1 are a significant cause of morbidity but little is known about the natural history of these lesions.
Objectives:
- The purpose of this study is to monitor the natural history of plexiform neurofibromas and to evaluate the usefulness of volumetric MRI tumor measurements in this disease.
- Other goals of the study are to provide a body of normative data on the growth rate of plexiform neurofibromas and to establish a tissue repository and pathology review center to allow future studies of the pathogenesis of neurofibromas and clinical trials of potential therapeutic agents.
Design
- This study is coordinated by Dr. Bruce Korf, and was initiated when he was at the Partners Center for Human Genetics, Boston, MA.
Detailed Description
Background: -Plexiform neurofibromas in patients with NF1 are a significant cause of morbidity but little is known about the natural history of these lesions. Objectives: * The purpose of this study is to monitor the natural history of plexiform neurofibromas and to evaluate the usefulness of volumetric MRI tumor measurements in this disease. * Other goals of the study are to provide a body of normative data on the growth rate of plexiform neurofibromas and to establish a tissue repository and pathology review center to allow future studies of the pathogenesis of neurofibromas and clinical trials of potential therapeutic agents. Design - This study is coordinated by Dr. Bruce Korf, and was initiated when he was at the Partners Center for Human Genetics, Boston, MA.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Monitor natural history of plexiform neurofibromas
Time Frame: 3 years
Monitor natural history of plexiform neurofibromas
Usefulness of volumetric MRI measurements
Time Frame: 4 years
Usefulness of volumetric MRI measurements
Secondary Outcomes
- Establish tissue repository & pathology reviews center(3 years)
- Body of data regarding growth rate of plexiform neurofibromas(3 years)