Yoga and fatty liver

Recruiting

Brief Summary: Given the high load of NAFLD in India(nearly 20-32% of the urban population),it is important to evaluate cost-effective strategies to facilitate itsreversal to normal. There are no specific and effective pharmacological agentsavailable for the treatment of NAFLD. If yogic exercise is proved to be beneficial for weight andmetabolism in subjects with NAFLD, it would present as a cost-effective, simpletechnique and could be recommended for management of NAFLD and itsconsequences. Obesity is an important public disease that has seriousimplication on society because of associated complications. Sedentarylifestyle is the main cause of obesity and regular physical activity isrecommended as the most important therapeutic option (ACC and AHA guidelines onobesity). However, a substantial proportion of obese persons find it difficultto adhere to such recommendations. This underlines the importance of yoga as analternative to physical activity protocols recommended in the guidelines. Besides, yoga can be practicedindoors. Thus, it can be practiced in densely populated metropolitan citieswhere open parks etc are not available for physical exercises like sports andrunning. Moreover, yoga can also be practiced in adverse weather conditions.The study will validate the replacement of yoga which can be practiced moreconveniently then other forms of physical exercises/activities.

Recruitment & Eligibility

Inclusion Criteria

Body Mass index (25-35 Kg/m2) 2.
Diagnosed to have NAFLD on ultrasonography/fibroscan/liver biopsy 3.Intend to follow up regularly will be included in the study.

Exclusion Criteria

Known or detected case of diabetes mellitus 2.
Acute infections and advanced end-organ damage 3.
History of pancreatitis/ any pancreatic disease 4.
Presence of other liver diseases (alcoholic liver disease, hepatitis virus infection, autoimmune hepatitis, primary biliary cirrhosis, drug-induced liver damage etc) 5.
On any medication within last one month which could potentially influence insulin secretion and/or insulin sensitivity 6.
Pregnancy and lactation 7.
Severe end organ damage or chronic diseases: renal/ hepatic failure, any malignancy, nephrotic syndrome, malabsorption etc.
Contraindications for MRI scan, loss of any limb 9.
Diseases restricting moderate intensity physical activity and/or yoga exercises like Joint diseases, cardiovascular diseases.

Primary Outcome Measures

Name	Time	Method
Effect of yogic exercises on body composition, metabolic profile	baseline, 3 months and 6 months

Secondary Outcome Measures

Name	Time	Method
Effect of yogic exercises on liver and pancreatic fat	baseline and 6 months

Locations (1): All India Institute of Medical Sciences, New Delhi
🇮🇳
South, DELHI, India
All India Institute of Medical Sciences, New Delhi
🇮🇳South, DELHI, India
Dr Naval K Vikram
Principal investigator
01126593678
navalvikram@gmail.com