A prospective study on prediction of efficacy of preoperative radiochemotherapy for advanced rectal cancer using liquid biops
Not Applicable
Recruiting
- Conditions
- Advanced Rectal Cancer
- Registration Number
- JPRN-UMIN000045355
- Lead Sponsor
- Wakayama medical university
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 10
Inclusion Criteria
Not provided
Exclusion Criteria
Patient unable to give consent
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The correlation of the dose of ctDNA and exosome DNA during treatment and the survival.
- Secondary Outcome Measures
Name Time Method Correlation between ctDNA and exosome DNA amounts before, during, and after treatment and recurrence-free survival time Correlation between ctDNA, exosome DNA amount and tumor markers Correlation between ctDNA, exosome DNA amount, response rate of neoadjuvant chemotherapy (RECIST Ver1.1), and disease control Correlation between the amount of ctDNA and exosome DNA and the rate of decrease in the SUVmax value of the primary tumor determined by PET-CT examination Correlation between ctDNA, exosome DNA amount and histological treatment effect (grade based on tumor cell disappearance rate according to Evans criteria) Correlation between ctDNA, exosome DNA amount and resection rate ctDNA, exosome DNA amount and radical resection rate (R1 or R0; R1: state with no macroscopic residual cancer, R0: state with no histological residual cancer) Comparative study of the amount of ctDNA and exosome DNA of the target gene and immunostaining results in surgical resection specimens