Bryostatin 1 in Treating Patients With Metastatic Kidney Cancer
- Registration Number
- NCT00003968
- Lead Sponsor
- National Cancer Institute (NCI)
- Brief Summary
Phase II trial to study the effectiveness of bryostatin 1 in treating patients who have metastatic kidney cancer. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
- Detailed Description
OBJECTIVES:
I. Determine the objective response rate to bryostatin 1 in patients with advanced renal cell carcinoma.
II. Assess the toxicities of this treatment regimen in this patient population. III. Determine the time to disease progression in patients receiving this treatment regimen.
IV. Determine the overall survival of this patient population treated with this regimen.
OUTLINE:
Patients receive bryostatin 1 IV over 1 hour on days 1, 8, and 15. Treatment continues every 4 weeks in the absence of unacceptable toxicity or disease progresssion.
Patients are followed every 3 months for 2 years, every 6 months for 3 years, and then annually thereafter.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 35
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Arm I bryostatin 1 Patients receive bryostatin 1 IV over 1 hour on days 1, 8, and 15. Treatment continues every 4 weeks in the absence of unacceptable toxicity or disease progresssion.
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (17)
Kimball Medical Center
🇺🇸Lakewood, New Jersey, United States
South Jersey Hospital - Millville
🇺🇸Millville, New Jersey, United States
Riverview Medical Center
🇺🇸Red Bank, New Jersey, United States
Community Medical Center
🇺🇸Toms River, New Jersey, United States
Delaware County Memorial Hospital
🇺🇸Drexel Hill, Pennsylvania, United States
Bon Secours-Holy Family Health System
🇺🇸Altoona, Pennsylvania, United States
Pottstown Memorial Regional Cancer Center
🇺🇸Pottstown, Pennsylvania, United States
Fox Chase Cancer Center at Virtua-Memorial Hospital Burlington County
🇺🇸Mount Holly, New Jersey, United States
Pinnacle Health Hospitals
🇺🇸Harrisburg, Pennsylvania, United States
North Penn Hospital
🇺🇸Lansdale, Pennsylvania, United States
Hunterdon Regional Cancer Center
🇺🇸Flemington, New Jersey, United States
Fox Chase Cancer Center
🇺🇸Philadelphia, Pennsylvania, United States
Saint Mary Medical Center
🇺🇸Langhorne, Pennsylvania, United States
Conemaugh Memorial Hospital
🇺🇸Johnstown, Pennsylvania, United States
Paoli Memorial Hospital
🇺🇸Paoli, Pennsylvania, United States
St. Francis Medical Center
🇺🇸Trenton, New Jersey, United States
Reading Hospital and Medical Center
🇺🇸Reading, Pennsylvania, United States