Combined effects of timing of eating and exercise on blood sugar control in individuals with type 2 diabetes

Not Applicable

Completed

• Conditions: Type 2 diabetes; Overweight/Obesity; Metabolic and Endocrine - Diabetes; Diet and Nutrition - Obesity

• Registration Number: ACTRN12619001222134
• Lead Sponsor: Dr Evelyn Parr

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-09-04
• Study Completion: 2023-10-10
• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 17

Inclusion Criteria

•Aged 35 to 65 years old
•Diagnosed (by a GP/endocrinologist) with type 2 diabetes mellitus (T2D), with an HbA1c between 6.5% - 9.9%, and either diet-controlled or taking a maximum of two oral antihyperglycemic agents (excluding sulphonylureas, insulin and GLP-1 agonists)
•Body mass index (BMI) between 25 - 45 kg/m2 (but total mass not >200 kg due to DXA measures)

Exclusion Criteria

•Meeting current guidelines for physical activity (i.e. greater than 150 minutes of moderate physical activity per week for greater than 4 weeks);
•Taking glucose lowering medications which recommend not fasting (i.e. sulphonylureas, or insulin) or requiring injecting (i.e. GLP-1 agonists);
•Currently following a strict diet (i.e. vegan, coeliac/gluten free, ketogenic);
•Participate in regular fasting (defined as fasting for equal to or greater than 16 h per day or having completed twelve 24-h fasts within the past year);
•Participating in shift work (i.e. greater than 3 h between 10 pm and 5 am for 1 day per week (more than 50 days per year))
•Not weight stable (greater than 5 kg change over last 3 months);
•On prescribed medications required to be taken with food in the early morning or late evening or taking other prescribed medications for greater than 3 months;
•Current smoker (tobacco, nicotine or marijuana) or within 3 months of quitting;
•Women who are pregnant, breastfeeding (within 24 wk);
•Psychopharmacological treatment that has not been stable for more than 3 months;
•Medications known to promote weight gain, weight loss or interact with glucose metabolism (i.e. corticosteroids);
•Diagnosed gastrointestinal conditions, surgery (i.e. bariatric) or impaired nutrient absorption;
•Known physical activity contraindications;
•Major illness/physical problems (acute or chronic) that may limit the ability to perform walking on a treadmill for 15 minutes;
•Previous hospitalisation/treatment for cardiac event.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Area under the curve for venous glucose concentrations across each condition for 14-hours[ Measured every hour from 8 am to 10 pm, and collected every 30 min for 2 hours after each meal (total of 26 measures).]