Cardiovascular Events Related to the Coronary Artery Treated by Surgical or Percutaneous Revascularization in Patients With Stable Multivessel Coronary Artery Disease: A Long-Term Comparison With Medical Therapy - Target Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,695
- 主要终点
- Non-fatal myocardial infarction related to the treated coronary artery
研究概览
简要总结
This retrospective cohort study evaluates cardiovascular events directly related to treated coronary arteries in patients with stable multivessel coronary artery disease. Outcomes in patients undergoing coronary artery bypass grafting or percutaneous coronary intervention will be compared with those receiving optimized medical therapy alone. This study aims to improve understanding of how different treatment strategies impact long-term vessel-related outcomes in patients with stable multivessel coronary artery disease.
详细描述
Previous studies evaluating coronary revascularization strategies have relied on broad composite endpoints, which may include events unrelated to the treated vessel. This study focuses on vessel-related outcomes, specifically non-fatal myocardial infarction and cardiac death attributable to the treated coronary artery. Patients were selected from the MASS (Medicine, Angioplasty, or Surgery Study) database at a single tertiary center. By analyzing vessel-specific events, this study aims to provide a more accurate assessment of the long-term impact of different treatment strategies in stable multivessel coronary artery disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with stable multivessel coronary artery disease, defined as ≥70% stenosis in at least two major epicardial coronary arteries, with documented myocardial ischemia and clinical indication for surgical, percutaneous, or medical treatment.
排除标准
- •Patients with limited life expectancy, severe left ventricular dysfunction (ejection fraction <35%), recent acute coronary syndrome, recent revascularization procedures, significant valvular disease, chronic kidney disease (creatinine ≥2.0 mg/dL), active malignancy, or inability to complete long-term follow-up.
研究组 & 干预措施
Coronary Artery Bypass Grafting (CABG)
Patients with stable multivessel coronary artery disease treated with surgical coronary artery bypass grafting.
干预措施: Coronary Artery Bypass Grafting (Procedure)
Percutaneous Coronary Intervention (PCI)
Patients with stable multivessel coronary artery disease treated with percutaneous coronary intervention.
干预措施: Percutaneous Coronary Intervention (Procedure)
Medical Therapy
Patients with stable multivessel coronary artery disease treated exclusively with optimized medical therapy.
干预措施: Optimized Medical Therapy (Other)
结局指标
主要结局
Non-fatal myocardial infarction related to the treated coronary artery
时间窗: Up to 5 years of follow-up
Cardiac death attributable to the treated coronary artery
时间窗: Up to 5 years of follow-up
次要结局
未报告次要终点
研究者
Thiago Ovanessian Hueb
MD, PhD
Instituto do Coracao