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Clinical Trials/NCT07362108
NCT07362108CompletedNot Applicable

Cardiovascular Events Related to the Coronary Artery Treated by Surgical or Percutaneous Revascularization in Patients With Stable Multivessel Coronary Artery Disease: A Long-Term Comparison With Medical Therapy - Target Trial

Instituto do Coracao0 sites1,695 target enrollmentStarted: January 1, 1995Last updated:
Conditions
Interventions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Enrollment
1,695
Primary Endpoint
Non-fatal myocardial infarction related to the treated coronary artery

Study Overview

Brief Summary

This retrospective cohort study evaluates cardiovascular events directly related to treated coronary arteries in patients with stable multivessel coronary artery disease. Outcomes in patients undergoing coronary artery bypass grafting or percutaneous coronary intervention will be compared with those receiving optimized medical therapy alone. This study aims to improve understanding of how different treatment strategies impact long-term vessel-related outcomes in patients with stable multivessel coronary artery disease.

Detailed Description

Previous studies evaluating coronary revascularization strategies have relied on broad composite endpoints, which may include events unrelated to the treated vessel. This study focuses on vessel-related outcomes, specifically non-fatal myocardial infarction and cardiac death attributable to the treated coronary artery. Patients were selected from the MASS (Medicine, Angioplasty, or Surgery Study) database at a single tertiary center. By analyzing vessel-specific events, this study aims to provide a more accurate assessment of the long-term impact of different treatment strategies in stable multivessel coronary artery disease.

Study Design

Study Type
Observational
Observational Model
Cohort
Time Perspective
Retrospective

Eligibility Criteria

Ages
18 Years to — (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Patients with stable multivessel coronary artery disease, defined as ≥70% stenosis in at least two major epicardial coronary arteries, with documented myocardial ischemia and clinical indication for surgical, percutaneous, or medical treatment.

Exclusion Criteria

  • Patients with limited life expectancy, severe left ventricular dysfunction (ejection fraction <35%), recent acute coronary syndrome, recent revascularization procedures, significant valvular disease, chronic kidney disease (creatinine ≥2.0 mg/dL), active malignancy, or inability to complete long-term follow-up.

Arms & Interventions

Coronary Artery Bypass Grafting (CABG)

Patients with stable multivessel coronary artery disease treated with surgical coronary artery bypass grafting.

Intervention: Coronary Artery Bypass Grafting (Procedure)

Percutaneous Coronary Intervention (PCI)

Patients with stable multivessel coronary artery disease treated with percutaneous coronary intervention.

Intervention: Percutaneous Coronary Intervention (Procedure)

Medical Therapy

Patients with stable multivessel coronary artery disease treated exclusively with optimized medical therapy.

Intervention: Optimized Medical Therapy (Other)

Outcomes

Primary Outcomes

Non-fatal myocardial infarction related to the treated coronary artery

Time Frame: Up to 5 years of follow-up

Cardiac death attributable to the treated coronary artery

Time Frame: Up to 5 years of follow-up

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor Class
Other Gov
Responsible Party
Principal Investigator
Principal Investigator

Thiago Ovanessian Hueb

MD, PhD

Instituto do Coracao

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