Impact of Serum Testosterone Level on Angiographic Complexity of Coronary Lesions in Premature Ischemic Egyptian Males
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Serum testosterone level
研究概览
简要总结
This study aims to investigate the association between serum testosterone levels and the angiographic complexity of coronary artery lesions in male patients under 45 years of age presenting with premature ischemic heart disease.
详细描述
Coronary artery disease (CAD) remains a leading cause of morbidity and mortality worldwide. While traditionally associated with older populations, there is a growing incidence of premature CAD.
Testosterone, the primary male sex hormone, exerts various physiological effects beyond its role in reproductive function. It influences muscle mass, fat distribution, insulin sensitivity, and vascular tone. Low testosterone levels have been associated with adverse metabolic profiles, including increased adiposity, dyslipidemia, and insulin resistance, all of which are established risk factors for atherosclerosis. Furthermore, testosterone deficiency has been linked to endothelial dysfunction, a critical early event in the development of atherosclerotic plaques.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 45 Years（Child, Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Male patients aged <45 years.
- •Diagnosed with premature ischemic heart disease.
- •Undergoing elective coronary angiography for suspected coronary artery disease (CAD) .
排除标准
- •History of acute coronary syndrome within the preceding 3 months.
- •Prior diagnosis of hypogonadism or history of testosterone replacement therapy or anabolic steroid use.
- •Active neoplasm or history of chemotherapy.
- •Known hepatic cirrhosis, chronic kidney disease, or end-stage renal disease.
- •Use of medications known to affect sex hormone levels (e.g., spironolactone, ketoconazole).
- •Endocrine disorders such as sickle cell anemia or celiac disease.
结局指标
主要结局
Serum testosterone level
时间窗: Immediately after angiography (Up to 1 hour)
Serum testosterone level will be measured.
次要结局
未报告次要终点
研究者
Remon Saleh Adly
Lecturer of Cardiovascular, Faculty of Medicine, Sohag University, Sohag, Egypt.
Sohag University