The MAGPIE Study: Multi-cancer genomic risk assessment to target screening in general practice patients aged 45-59.

niversity of Melbourne0 个研究点目标入组 149 人开始时间: 2023年1月17日最近更新: 2024年7月29日

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•Potential participants are those seeing a consented GP at the recruited clinics who meet all of the following criteria:
•Are aged between 45 and 59 years
•Are able to read and write English and competent to give informed consent
•Are contactable over the next six months for the study follow-up

•- Have been diagnosed with any of breast, prostate, colorectal cancer or melanoma;
•- Have any alarm symptoms that are indicative of the cancers included in the risk assessment:
•Once or more and uninvestigated:
•- Blood in stool or urine
•oFor more than four weeks and uninvestigated:
•- Problems with urination
•- Diarrhoea
•- Unexplained weight loss
•- An unusual pain, lump or swelling anywhere in your body
•- A new or changed spot on your skin;
•- Have a known genetic predisposition to any of the four cancers in question or, a first-/second-degree relative with a genetic predisposition and the participants has not had genetic testing themselves. This is defined by a mutation in any of the following genes:
•- CRC: Lynch syndrome (MLH1, PMS2, MSH2, MSH6, EPCAM), familial adenomatous polyposis (APC);
•- BrCa: BRCA1, BRCA2, PALB2, ATM, CHEK2;
•- PrCa: BRCA1, BRCA2, HOXB13;
•- Melanoma: CDKN2A/p16.

发起方

niversity of Melbourne