Dietary polyphenols as modulators of lipid oxidation and mitochondrial function in overweight volunteers

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 60

Inclusion Criteria

- Overweight men and women (BMI>=25kg/m2- 34.9kg/m2),
- Aged 20-35 and 35-50 years
- Caucasian
- Normal fasting glucose (< 6.1 mmol/L)
- Normal blood pressure (systolic blood pressure 100-140 mmHg, diastolic blood pressure 60-90 mmHg)
- Weight stable in last 3 months (± 2kg).

Exclusion Criteria

- Women lactating, pregnant or (post) menopausal
- Regular smokers
- People with intensive fitness training, eg. athletes (>= 3 per week >= 1 hour training)
- Habitual consumption of green tea (more than 1 cup per day) or products containing green tea extract
- Total caffeine consumption > 300 mg/day (1 can of cola or 2 cups of regular coffee or 2 cups of black tea or 1 cup of coffee and 1 cup of black tea or other combinations)
- Alcohol intake >20 g/day (2 glasses of beer or wine)
- Any dietary vitamins or dietary supplements
- Diabetes mellitus (defined as FPG >= 7.0 mmol/l and/or 2hPG >= 11.1 mmol/l)
- Serious pulmonary, cardiovascular, hepatic or renal disease
- History of cardiovascular disease
- All other relevant medical disorders that potentially interfere with this trial (e.g. history of gastro-intestinal, liver or thyroid disorders)
- Current use of medication interfering with study intervention or interfering with study endpoints/hypotheses (e.g. medication containing caffeine like analgesics, anorectics and analeptics)
- Not to be able to understand the study information
- Subjects on a special diet or vegetarian
- Blood donation 2 months prior to the study and during the study
- Participation in other studies
- Drug use
- Use of anti-coagulant medication

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary study parameter is the difference in postprandial fat oxidation<br /><br>after the 3 polyphenol conditions</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>As secondary endpoints, differences in the systemic and local tissue lipolysis,<br /><br>mitochondrial function, oxidative stress, insulin sensitivity and body<br /><br>composition between the various polyphenol supplements are examined.</p><br>