Titanium-Prepared Platelet Rich Fibrin on Non-Surgical Periodontal Therapy: A Split-Mouth Randomized Controlled Clinical Trial

This split-mouth randomized controlled clinical trial aims to assess the adjunctive role of titanium-prepared platelet-rich fibrin (t-PRF) on non-surgical periodontal therapy (scaling and root planing, SRP) in patients with chronic periodontitis. Systemically healthy patient of age between 18-55 years diagnosed with Periodontitis Stage III Grade A will be included.  Patients with contralateral periodontal sites exhibiting similar probing pocket depths (5-6 mm) will receive scaling and root planing (SRP) in all affected areas. Following SRP, test sites will be treated with t-PRF membranes prepared from the patient’s own blood using titanium tubes, while in control sites no additional treatment will be given. Clinical outcomes, including probing pocket depth (PPD), clinical attachment level (CAL), plaque index (PI), gingival index (GI), and bleeding on probing (BOP), will be recorded at baseline and at 6 weeks post-treatment. The allocation of test and control sites will be randomized, and the clinical examiner will be blinded. Statistical analyses will compare the clinical improvements between the two groups, with the expectation that t-PRF will enhance healing and improve periodontal parameters more effectively than scaling and root planing alone.