Comparative Study of Perioperative Cardiac Injury in Patients With Functional Adrenal Tumors

• Conditions: Primary Aldosteronism; Adrenal Tumor; Cushing s Syndrome; Pheochromocytoma/Paraganglioma (PPGL)

• Registration Number: NCT07182175
• Lead Sponsor: Peking University First Hospital

Brief Summary

The main goal of this study is to follow patients with functional adrenal tumors during the time before and after their surgery.

The main questions it aims to answer are:

* What heart and blood pressure changes do patients with different types of adrenal tumors have before surgery?

* What factors affect how the heart and blood pressure recover after surgery?

* Do the heart and blood pressure conditions before surgery influence recovery and the risk of heart or brain problems after surgery?

Patients will have heart ultrasound checks and health monitoring before and after surgery. The results will help doctors choose the right medicines before surgery, better understand possible risks during the operation, and make safer treatment plans for patients with functional adrenal tumors.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-09-19
• Primary Completion: 2024-11-17
• Status Verified: 2025-09
• Study First Submitted: 2025-09-11
• Study First Submitted QC: 2025-09-11
• Last Update Submitted: 2025-09-11
• Study First Posted: 2025-09-19
• Last Update Posted: 2025-09-19
• Study Completion: 2026-05-29

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

• Patients diagnosed in the Department of Urology, Peking University First Hospital with pheochromocytoma and paraganglioma (PPGL), primary aldosteronism (PA), or Cushing syndrome (CS);
• Written informed consent obtained.

Exclusion Criteria

• Patients with PPGL, PA, or CS who receive medication or conservative treatment and are not eligible for surgical resection;
• Patients with communication disorders or severe physical impairments such as aphasia, or visual/hearing disabilities;
• Patients with severe mental illness who cannot cooperate with the study;
• Pregnant women or patients otherwise deemed unsuitable for participation by the investigators.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Recovery of cardiac function after adrenal surgery	from enrollment to 4,24,48 weeks after surgery	global longitudinal stress

Secondary Outcome Measures

Name	Time	Method
Recovery of blood pressure after adrenal surgery	from enrollment to 4,24,48 weeks after surgery	Decrease in 24h average blood pressure

Trial Locations

Locations (1)

Peking University First Hospital; 🇨🇳 Beijing, China