Prehospital CPAP Versus Usual Care for Acute Respiratory Failure: a Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- proportion of patients in each group endotracheally intubated prior to hospital discharge or death
研究概览
简要总结
The purpose of this study is to evaluate the effectiveness of continuous positive airway pressure ventilation when applied by paramedics to individuals with severe breathing difficulties in the prehospital setting.
详细描述
Continuous positive airway pressure ventilation (CPAP) has been shown to be effective in avoiding endotracheal intubation (ETI) for patients with acute respiratory failure in hospital but despite several case series, the effectiveness of the prehospital application of CPAP by paramedics has not been studied in a randomized fashion. We performed a prospective, randomized, non blinded trial to determine whether patients in acute respiratory failure treated with CPAP in the prehospital setting had lower overall ETI rates than those treated with standard care.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 16 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •severe dyspnea
- •respiratory rate >25 breaths/minute
- •hemodynamically stable
- •able to cooperate with ventilatory support measures
- •assessed by paramedics as being in urgent need of ETI and/or manual positive pressure ventilation
- •a trip destination of the QEII Health Sciences Center or Dartmouth General Hospital
排除标准
- •require ETI for immediate airway protection
- •respiratory rate < 8 breaths/minute
- •evidence of hemodynamic instability
- •cardiac ischemia
- •any chest pain within 3 hours of presentation
- •valid "do not resuscitate" advanced directive
- •an inadequate supply of portable oxygen
结局指标
主要结局
proportion of patients in each group endotracheally intubated prior to hospital discharge or death
次要结局
- mortality
- hospital length of stay
- critical care unit length of stay