Evaluation of clinical and functional parameters in patients with Hemophilia aged above 60 years

Recruiting

• Conditions: Hemophilia; D66; Hereditary factor VIII deficiency; Hereditary factor IX deficiency; D67

• Registration Number: DRKS00010176
• Lead Sponsor: Goethe-Universität Frankfurt

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-06-12
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

? aged older than 60 years
? confirmed diagnosis of hemophilia A or B
? informed consent signed

Exclusion Criteria

? younger than 60 years
? no confirmed diagnosis of hemophilia A or B
? no informed consent
? lack of comprehension of study documents

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Bleeding rate and bleeding pattern in the preceding year<br>, duration and kind of Substitution therapy,<br>data collection by CRF at study start and annually

Secondary Outcome Measures

Name	Time	Method
Interaction of clinical, emotional and functional parameters as well as influence of age, Co-morbidities and medication;<br>Annual data collection by CRF and validated questionnaires (German Versions):<br><br>Clinical:<br>? Joint Condition (Hemophilia Joint Health Score, HJHS) <br>? Co-Morbidity and Co-Medication<br>? Cause and duration of hospitalization <br>? Level of care<br>? death/Cause of death<br><br>Emotional:<br>? Depression (Geriatric depressions scale questionnaire, GDS-15)<br>? Health-related quality of life: SF-36v2 (© QualityMetric Incorporated, USA, 2006)<br><br>Functional:<br>? physical functionality: Haemophilia Activity List 2.0 2015<br>? Tinetti Motility Test (Balance & Gait)<br><br>Comparison of Co-Morbidity with normal population (aggregated Data of RKI)