DRKS00032671尚未招募不适用

Identification and characterization of antimicrobial antibodies in the serum of patients with periodontitis

Abteilung für Zahnerhaltung & Parodontologie // Klinik für Zahn- Mund- und Kieferheilkunde0 个研究点目标入组 200 人开始时间: 2024年2月15日最近更新: 2024年8月19日

适应症

试验速览

暂无简介。

•The following general criteria must be met for inclusion in the study:
•- Capacity to provide informed consent
•- Patients with periodontitis as well as individuals without a diagnosis of periodontitis, provided all other inclusion criteria are met, and no exclusion criteria apply.
•Additionally, the following criteria must be checked and satisfied immediately before blood collection:
•- Puncture site: Free from lesions or infections
•- Presence of a signed informed consent form for participation in the study

•- Existing cytopenias (leukocytes <1,500/µl, platelets <50,000/µl, or hemoglobin <12 g/dl)
•- Cardiac complications (e.g., pulmonary arterial hypertension).
•- Presence of infectious diseases.
•- No blood sample collection for B-cell isolation in individuals with a body weight <50 kg
•- Blood donation or significant blood loss (e.g., surgery) within the last 8 weeks (men) or 12 weeks (women).
•- Blood pressure: systolic: 100–180 mm Hg, diastolic: below 100 mm Hg.
•- Pulse: within the normal range, frequency 50–110/min; potential donors engaged in intense sports activities with a pulse rate below 50/min may be considered.
•- Within one week after minor surgery (e.g., biopsy, tooth extraction, etc.), or 2 or 3 months (as mentioned above) after major surgery (e.g., involving the opening of the chest cavity or abdominal cavity) or any other surgery with an increased risk of post-operative bleeding
•- Any deterioration in the general health status, e.g., weight loss >2 kg, diabetic metabolic state, pulmonary exacerbation, or loss of lung function (FEV1 > 10%) in the past 3 months
•- No fever

发起方

Abteilung für Zahnerhaltung & Parodontologie // Klinik für Zahn- Mund- und Kieferheilkunde