Action of two forms of ozone therapy application on clinical and biochemical parameters after wisdom teeth extraction: clinical, triple blind and randomized study

Not Applicable

• Conditions: Pain, Postoperative; Edema; Trismus; C23.550.767

• Registration Number: RBR-8zypz4p
• Lead Sponsor: niversidade Estadual Paulista Júlio de Mesquita Filho

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-12-13
• Last Update Posted: 19 December 2023
• Study Completion: 2024-03-04

Recruitment & Eligibility

• Status: Recruitment completed
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Patients with favorable systemic and local health conditions; be between 16 and 35 years of age; both genders; with indication of tooth extraction of the lower third molars (elements 38 and 48), in position A or B and Pell & Gregory classification I or II, with at least 2/3 of the root formed

Exclusion Criteria

Mandibular third molars in position C and Pell & Gregory classification III; signs of local manifestations such as pericoronitis, cysts and odontogenic tumors associated or not with the third molar, trauma in the region, presence of infection or periodontal disease; patients with any systemic disease that interferes with the results of the procedure or who cannot use the drugs present in the study; presence of a history of hypersensitivity to drugs present in the study and to products used in the procedure, such as: 0.5% alcoholic chlorhexidine solution, 0.12% chlorhexidine digluconate solution and 2% mepivacaine hydrochloride solution with epinephrine 1:100,000; women who are menstruating, pregnant or breastfeeding during the study period; patients using medications to control psychiatric diseases, corticosteroids, estrogens and androgens

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Clinically compare the effectiveness of protocols in controlling postoperative symptoms (pain) using the visual analogue scale (VAS) as a method, as follows: a sheet will be provided with a 10cm straight line on which the patient will be instructed to mark a point between the extremes "no pain" and "unbearable pain

Secondary Outcome Measures

Name	Time	Method
To analyze the concentration of salivary biomarkers indicating tissue inflammation: total protein (PT), acid phosphatase (FA), alkaline phosphatase (FAL), aspartate aminotransferase (AST), alanine aminotransferase (ALT) present in the saliva of patients in each experimental group in each analysis time through biochemical evaluation;To evaluate whether ozone therapy is effective in modulating oxidative stress based on the analysis of the biomarker of thiobarbituric acid reactive species (TBARS)