A Study of the Effect of Synbiotic Supplementation and/or Dietary Intervention With Fruits and Vegetables on the Risk of Metabolic Dysfunction and Overweight or Obesity Among Hong Kong Chinese
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Obesity
- Sponsor
- Chinese University of Hong Kong
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Change in body weight at week 8 compared with baseline
- Last Updated
- 3 years ago
Overview
Brief Summary
Synbiotic is a nutritional supplement that contains both prebiotic and probiotic. Probiotics are beneficial microorganisms, while prebiotics are foods that help the growth of beneficial microorganisms in the gut. In the study, dietary intervention with fruits and vegetables and/or synbiotic supplementation with be administered to Hong Kong Chinese subjects for eight weeks. Changes in the composition and diversity of intestinal microbiota, and markers indicative of obesity, chronic inflammation and metabolic dysfunction will be assessed throughout the whole period. This study will further provide a scientific basis for the intake of synbiotics for reducing the risk of overweight and obesity among Hong Kong Chinese. Furthermore, the results will bridge to further research into the most desirable gut microbiome profile, hence facilitating personalised nutrition for optimal health.
Detailed Description
This is an 8-week randomized controlled dietary interventional trial.The objectives of this study include: * To investigate the effects of synbiotic supplementation and/or dietary intervention with fruits and vegetables on gut microbial diversity and composition, and on inflammation, metabolic functioning, overweight and obesity among Hong Kong Chinese * To study whether the changes in gut microbial diversity and composition upon the interventions in Hong Kong Chinese are correlated with metabolic functioning and inflammation, as well as overweight or obesity
Investigators
Lauw Susana
Principal Investigator
Chinese University of Hong Kong
Eligibility Criteria
Inclusion Criteria
- •Waist circumference ≥90cm in men and ≥80cm in women
- •BMI \>23.0kg/m2
Exclusion Criteria
- •Practicing dietary restrictions
- •Using cholesterol-lowering, antihypertensive, anti-inflammatory drugs or Chinese medicines
- •Consuming laxatives, any gastrointestinal medication, probiotics, prebiotics, synbiotics or antibiotics
- •Alcohol abuser
- •Currently pregnant or lactating
Outcomes
Primary Outcomes
Change in body weight at week 8 compared with baseline
Time Frame: Week 0, 8
Body weight in kilogram
Change in Body Mass Index (BMI) at week 8 compared with baseline
Time Frame: Week 0, 8
BMI = Body weight (in kilograms) divided by square of body height (in meters)
Change in body fat percentage at week 8 compared with baseline
Time Frame: Week 0, 8
Body fat percentage is assessed by bioimpedence
Secondary Outcomes
- Change in fasting insulin at week 8 compared with baseline(Week 0, 8)
- Changes in fasting lipids at week 8 compared with baseline(Week 0, 8)
- Change in fasting glucose at week 8 compared with baseline(Week 0, 8)
- Use of 16S rRNA gene sequencing to assess the changes in the composition of the gut microbiota (bacteriome) of stool samples at week 8 compared with baseline(Week 0, 8)