Split face study comparing efficacy of microneedling with tranexamic acid versus microinjections with tranexamic acid in melasma in Indian skin

After applying inclusion and exclusion criteria .History and written consent from the patient is taken For Group A Patients Topical anesthesia will be applied over lesions under occlusion for 45 minutes Microneedling will be done with DermaPen using the lowest speed with the penetration depth of the needle from 0.25 to 1 mm This will be followed by application of about 0.5 ml TXA (4mg/mL) to the melasma area After cleaning with betadine topical fusidic acid applied under occlusive dressing for the same day All patients will be advised to use sunscreens regurarly The procedure will be repeated every 2 weeks for a maximum of 6 sessions For Group B Patients Topical anesthesia will be applied over lesions under occlusion for 45 minutes Intradermal microinjection of about 4 mg/mL Tranexamic acid will be given in 1 mL insulin syringe with 30 gauge needle Keeping a distance of around 1 cm from each injection with a maximum of 8 mg in a single sitting After cleaning with betadine topical fusidic acid applied under occlusive dressing for the same day All patients will be advised to use sunscreens regularly The procedure will be repeated every 2 weeks for a maximum of 6 session Clinical improvement and side effects will be assessed after each session and at the end of 6 months The study will be concluded with the comparison of clinical improvement of both group A and group B study population