NCT02005718已完成3 期
Impact of Cholecalciferol on Endothelial Fucntion and Blood Biomarkers in Patients With Chronic Kidney Disease
适应症
干预措施
相关药物
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 36
- 主要终点
- Flow mediated dilation
研究概览
简要总结
Vitamin D deficiency is common in CKD and assciated with CV complications. Endothelial dysfucntion is common in CKD and is a harbinger of atherosclerosis. The study investigated the impact of Vitamin D on endothelial fucntion and blood biomarkers in CKD.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •CKD 3-4 Age 18-80
排除标准
- •Recent MI, CVA, malignancy active infection active inflammation High calcium already on Viatmin D therapy
研究组 & 干预措施
Vitamin D
Experimental
Cholecalciferol 300,000 twice
干预措施: Cholecalciferol (Drug)
结局指标
主要结局
Flow mediated dilation
时间窗: 16 weeks
次要结局
- CD28 null cell frequency(16 weeks)
- Blood biomarkers of endothelial function and inflammation(16 weeks)
研究者
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