DRKS00026098招募中不适用
Prospective study of prognostic markers of kidney damage in cardiorenal syndrome
niversitätsmedizin Göttingen0 个研究点目标入组 170 人开始时间: 2022年1月3日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 170
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 Years 至 one（—）
- 性别
- All
入选标准
- •Adult patients capable of consent
- •- Age = 18 years
- •- Outpatients able to consent and cooperate
- •- Written consent to study participation
- •- Patients with a cardio-renal risk profile on stable guideline medication for > 3 months (at least 1 of the following applies):
- •A) Patients for whom SGLT2 inhibitor therapy is planned as part of best clinical practice:
- •Diabetes mellitus II with nephropathy (group 1)
- •CKD and HFrEF (echocardiographically confirmed) (Group 2)
- •CKD without diabetes (Group 3)
- •CKD and HFpEF (Group 7)
- •B) independent of further treatment:
- •Patients with arterial hypertension without HFpEF (group 4)
- •Patients with arterial hypertension with HFpEF (group 5)
- •control group
- •Inclusion Criteria:
- •Outpatients and inpatients at the Clinic for Nephrology and Rheumatology
- •Age = 18 years
- •Written consent to study participation
- •No evidence of renal or cardiac disease on physical examination
排除标准
- •- Patients who have had a kidney transplant (NTX) or require dialysis
- •- Chronic renal insufficiency CKD stage> G4 (<15 ml / min according to the CKD EPI formula)
- •- Current acute kidney damage
- •- Postrenal obstruction
- •- (Proven) pulmonary hypertension in the context of causes other than heart failure (class 2)
- •- pregnancy or breastfeeding
- •- Circumstances that interfere with the implementation or interpretation of the measured variables, such as severely restrictive respiratory diseases, strongly fluctuating blood pressure values ??and others
- •- Presence of type I diabetes mellitus
- •- Active tumor disease
- •- Inflammatory or autoimmune disease that affects kidney function
- •- Circumstances that could interfere with the results of the Doppler sonographic evaluation (e.g. significantly restrictive respiratory diseases, strongly fluctuating blood pressure values, BMI> 40 kg / m2, etc.) Circumstances that could interfere with participation in the study (e.g. known non-adherence)
- •Control group
- •Exclusion criteria
- •Heart failure (HFpEF, HFmrEF, HFrEF)
- •diabetes mellitus
- •Refractory hypertension
- •Albuminuria> 30mg / g creatinine
- •eGFR <60 ml / min according to CKD-EPI
- •pathological urine sediment (e.g. significant hematuria, leukocyturia)
- •Active tumor disease
- •Active or uncontrolled inflammatory or autoimmune disease
- •CRP> 20 mg / l
- •Circumstances that could interfere with the results of the Doppler sonographic evaluation (e.g. clearly restrictive respiratory diseases, strongly fluctuating blood pressure values, BMI> 40 kg / m2 etc.)
- •Circumstances that could interfere with participation in the study (e.g. known non-adherence)
- •Pregnancy or breastfeeding
研究者
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