Evaluation of pancreas composition and function during return to normal glucose tolerance in type 2 diabetes
Completed
- Conditions
- Topic: Diabetes Research Network, Metabolic and EndocrineSubtopic: Type 2, Metabolic and Endocrine (all Subtopics)Disease: MetabolicNutritional, Metabolic, Endocrine
- Registration Number
- ISRCTN11969319
- Lead Sponsor
- ewcastle upon Tyne Hospitals NHS Foundation Trust
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 28
Inclusion Criteria
1. Type 2 diabetes duration less than 15 years
2. On treatment with diet alone or diet plus oral agents
3. BMI 35-45m/kg2
4. Listed for gastric bypass surgery
5. HbA1c < 10%
Exclusion Criteria
1. Waist circumference >150cm
2. Kidney dysfunction (serum creatinine >150 µmol/l)
3. Liver dysfunction (serum ALT > 2.5 times the upper limit of normal)
4. Contraindications to MRI (metal implants and claustrophobia)
5. Alcohol consumption >14 units per week
6. Treatment with thiazolidinediones, insulin, GLP1 analogues or steroids
7. History of bowel surgery or inflammatory bowel disease
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method First phase insulin response at baseline, 1 week after intervention and 8 weeks after surgery
- Secondary Outcome Measures
Name Time Method 1. Liver fat and hepatic insulin sensitivity at baseline, 1 week after intervention and 8 weeks after surgery<br>2. The treatment induced changes in pancreatic fat content at baseline, 1 week after intervention and 8 weeks after surgery