Alterations of Glycocalyx in Critical Illness and During Major Surgery and Approaches for Glycocalyx Protection. Effect of Parenteral Nutrition and Plasma Lipidome on GCX
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Endothelial Dysfunction
- Sponsor
- University Hospital Hradec Kralove
- Enrollment
- 15
- Locations
- 1
- Primary Endpoint
- Endothelial Glycocalyx Thickness
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
Characterisation of the lipidome and parenteral nutrition modulate the endothelial glycocalyx.
The aim of the study A is to detect any influence of the lipid emulsion on the endothelial glycocalyx in patients in critical care. The targeted cohort is patients on ICU with an indication for parenteral nutrition including lipid emulsion. 15 patients are planned to be enrolled.
Monitored variables: demographic data, type of the population, type of the lipid emulsion, selected variables of the lipid metabolism, sublingual microcirculation (SDF imaging),
Investigators
Vladimir Cerny
Clinical Professor
University Hospital Hradec Kralove
Eligibility Criteria
Inclusion Criteria
- •patients in ICU
- •indication for lipid administration as a part of TPN
Exclusion Criteria
- •shock or clinical/laboratory signs of tissue hypoperfusion
- •previous lipid infusions (within 3 months before entering study)
- •hyperlipidaemia
- •hyperglycaemia (over 10 mmol/l)
- •current or previous (within 72 hours before entering the study) use of propofol
- •pancreatitis
- •severe liver failure
- •current use of statins
Outcomes
Primary Outcomes
Endothelial Glycocalyx Thickness
Time Frame: One week within the ICU care
Endothelial glycocalyx thickness was measured indirectly by PBR, which is a lateral movement of the red blood cells from the median column in the microcirculation in micrometers. The higher the PBR is the more damaged the endothelial glycocalyx is.