Comparative study between cabergoline and intravenous calcium in the prevention of ovarian hyper stimulation in women with polycystic ovarian disease undergoing Intracytoplasmic sperm injection (ICSI ).

Phase 3

Recruiting

• Conditions: subfertility; ovarian hyperstimulation; Poly cystic ovarian disease; Reproductive Health and Childbirth - Fertility including in vitro fertilisation

• Registration Number: ACTRN12613000904774
• Lead Sponsor: Eman Elkattan

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-08-13
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

Subfertile women with polycystic ovarian disease
-serum FSH within normal limits( 1-12IU /l)
-at least 15 follicles or more ,more than 10 mm at the time of HCG administration

Exclusion Criteria

-patients need coasting for high risk of OHSS.
-patients need cycle cancellation.
-severe male infertility requiring testicular sperm extraction.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The Occurrence of ovarian hyper stimulation which can be diagnosed clinically by patient symptoms accompanied by ultrasonography and laboratory investigation [10 months];The severity of ovarian hyper stimulation which is detected by the need for ascitic drainage and the need for hospitalisation [10 months]

Secondary Outcome Measures

Name	Time	Method
chemical pregnancy rate :Positive (serum BHCG) 14 days following Embryo transfer[10 months];clinical pregnancy rate: positive pregnancy test and positive fetal heart beat by ultrasound after 6 weeks gestaional age[10 months];miscarriage rate: diagnosed by ultrasound /clinically[10 months];ectopic rate :diagnosed by ultrasound /clinically[10 months]