Comparison between continuous subcutaneous insulin infusion with multiple basal lispro infusion rates and multiple daily insulin injection with lispro and glargine

Not Applicable

Completed

• Conditions: Diabetes mellitus type one; Nutritional, Metabolic, Endocrine; Diabetes mellitus

• Registration Number: ISRCTN37153662
• Lead Sponsor: Disetronic Medical Systems AG (Switzerland)

Brief Summary

2008 Results article in https://doi.org/10.1111/j.1464-5491.2007.02365.x (added 22/09/2021)

Detailed Description

Not available

Study Timeline

• Study Completion: 2005-05-16
• Study Start: 2007-04-25
• Last Update Posted: 4 October 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

1. Type one diabetic patients (World Health Organisation [WHO] classification)
2. Between 18 and 60 years old
3. Have been diabetics for more than two years
4. Have been treated with CSII for at least six months prior to the study
5. HbA1c needs to be less than 8.5%
6. Patients should be familiar with carbohydrate counting and should be able to change insulin doses (either by pump or injections) based on changes in food intake and physical exercise

Exclusion Criteria

1. Poor motivation
2. Body Mass Index (BMI) greater than 30 kg/m^2
3. Treatment with daily insulin injections
4. Inability to handle pump therapy (pump handling, infusion set handling, compliance with treatment rules)
5. Untreated retinopathy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> Blood glucose variability as measure by standard deviation of mean blood glucose.<br><br> Data of the last month of each treatment period were analysed.<br>