Effect of a single low dose preoperative Erythropoietin administration on increasing hemoglobin level in patient undergoing Orthognathic surgery

Phase 4

Recruiting

• Conditions: Women patients with preoperative mild anemia (hemoglobin level 10-12 g/dL) undergoing Orthognathic surgery; Erythropoietin, Hemoglobin, Orthognathic surgery, Iron supplement, Anemia

• Registration Number: TCTR20220429008
• Lead Sponsor: Ministry of Higher Education, Science, Research and Innovation, Prince of Songkla University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-04-29
• Study Completion: 2024-03-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: 20

Inclusion Criteria

1. Women patients undergoing Orthognathic surgery
2. Patients age over 18 years
3. Mild anemic women with Hb concentration 10-12 g/dL
4. Serum ferritin 35 to 100 ng/mL
5. Healthy patients with ASA class 1-2
6. Body weight 40 to 80 kg

Exclusion Criteria

1. Uncontrolled hypertension
2. Seizures
3. Cardiovascular disease e.g. Stoke, Myocardial infarction
4. Current treatment with NSAIDs, antiplatelet and anticoagulants
5. History of thromboembolism event
6. Anemic conditions contraindicated to Erythropoietin and iron supplement administration e.g. Thalassemia trait, Aplastic anemia, Megaloblastic anemia
7. Current or previous treatment with Erythropoietin or iron supplement and blood transfusion within the last 30 days
8. Abnormal menstruation
9. Pregnancy and lactation

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Hemoglobin level The day before surgery Complete blood count

Secondary Outcome Measures

Name	Time	Method
/A N/A N/A