The Genetic Basis of Atrial Fibrillation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
研究概览
简要总结
The investigators' goal with this research is to:
- Establish a clinical database and a DNA bank for 1000 individuals with AF and 1000 individuals without AF.
- Directly test the hypothesis that known functional polymorphisms in the coding sequences and the promoter regions of cardiac genes (ion channels and genes known to affect survival in the setting of left ventricular dysfunction) predispose individuals to AF.
Over the past decade, advancing techniques and technologies for gene characterization have yielded significant clues as to the molecular mechanism of certain human heart rhythm disorders. The role of ion channel polymorphisms in subjects with AF is unknown. Similarly, it is also not known whether polymorphisms in other genes have an impact on the risk of AF.
The ability to characterize genomic "at-risk" profiles would have many potential benefits for patient care. Paramount among these is:
- Increased oversight or intervention of at-risk subjects, which might prevent unnecessary morbidity and mortality due to AF.
- Further insight into the pathogenesis of AF, which may lead to preventative or curative therapies.
详细描述
Atrial fibrillation (AF), a heart rhythm disorder, is a major health problem. As many as 3 million US persons are afflicted; this number is expected to rise significantly in coming decades because AF incidence is directly correlated with age. AF is significantly associated with cardiovascular morbidity and mortality.
Our goal with this research is to:
- Establish a clinical database and a DNA bank for 1000 individuals with AF and 1000 individuals without AF.
- Directly test the hypothesis that known functional polymorphisms in the coding sequences and the promoter regions of cardiac genes (ion channels and genes known to affect survival in the setting of left ventricular dysfunction) predispose individuals to AF.
Over the past decade, advancing techniques and technologies for gene characterization have yielded significant clues as to the molecular mechanism of certain human heart rhythm disorders. The role of ion channel polymorphisms in subjects with AF is unknown. Similarly, it is also not known whether polymorphisms in other genes have an impact on the risk of AF.
The ability to characterize genomic "at-risk" profiles would have many potential benefits for patient care. Paramount among these is:
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18+ years of age
- •Able to give informed consent
排除标准
- •Inability to provide informed consent