The Efficacy and Safety of Beta-blockers Drugs in Adults With Spinal Hemangioma: a Prospective Cohort Study
试验速览
- 阶段
- 4 期
- 发起方
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- Life-quality
研究概览
简要总结
Spinal hemangioma is one of the most common benign vertebral tumours. Being mostly asymptomatic, it is still associated with a pain syndrome especially if encroaches into the neural canal.
This study is organised to evaluate the efficacy and safety of β-blockers drugs in adults with spinal hemangioma.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •vertebral hemangioma
排除标准
- •symptomatic bradycardia
- •decompensated heart failure
研究组 & 干预措施
Previously treated + Atenolol
The investigators suppose the outcome might be compromised if patient has been previously treated, that's why it is going to be compared to the main cohort. The results are going to be analysed separately
干预措施: Atenolol Pill (Drug)
Previously treated + Propranolol
The investigators suppose the outcome might be compromised if patient has been previously treated, that's why it is going to be compared to the main cohort. The results are going to be analysed separately
干预措施: Propranolol Pill (Drug)
结局指标
主要结局
Life-quality
时间窗: 3 months and 6 months
Valid questionnaires based on the ones, approved by EuroQol Organization
Reducing tumor growth
时间窗: 3 months
MRI
Reducing tumor
时间窗: 6 months
MRI
次要结局
未报告次要终点