Aerosolisation During Respiratory Procedures

• Conditions: Droplet Spread; Healthy; Respiratory Tract Infections; Lung Infection

• Registration Number: NCT04741217
• Lead Sponsor: Guy's and St Thomas' NHS Foundation Trust

Brief Summary

Currently, a major issue within respiratory medicine is undertaking procedures that generate aerosolisation with the concern of spreading infection, such as the SARS-COV-2/COVID-19 virus. It is anecdotally reported that lung function testing and positive airways pressure devices used in clinical practice are aerosol generating procedures however the data to support this is limited. With the advent of high-speed imaging systems that can capture and quantify particle size and velocity we aim to investigate the aerosol generation in routine non-invasive positive pressure respiratory procedures.

Detailed Description

Not available

Study Timeline

• Status Verified: 2020-08
• Study First Submitted: 2021-02-03
• Study First Submitted QC: 2021-02-03
• Study First Posted: 2021-02-05
• Last Update Submitted: 2021-02-10
• Last Update Posted: 2021-02-15
• Study Start: 2021-03-01
• Primary Completion: 2021-09-01
• Study Completion: 2021-09-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Age 18-80 years
• Healthy subjects with no active medical conditions or previous pneumothorax
• Cognitively and linguistically able to follow instructions given in English and provide informed consent

Exclusion Criteria

• Significant respiratory, cardiac or neurological conditions or previous pneumothorax
• Smoking history greater than 10 pack years
• Acute illness at the time of assessment
• Allergies to latex, metals or local anaesthetic agents

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Characterisation of aerosolised respiratory droplets	1 year	Performed using high-speed imaging and particle size counters