Identifing medical predictors of anti-hypertensive effect of eplerenone
Not Applicable
- Conditions
- Hypertension
- Registration Number
- JPRN-UMIN000002479
- Lead Sponsor
- Department of Internal Medicine, School of Medicine, Keio University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
Not provided
Exclusion Criteria
1. renal dysfunction (eGFR<50ml/min or male Cr>2.0mg/dl, female Cr>1.8mg/dl) 2. liver dysfunction 3. serum K>5.0mEq/l before intervention 4. diabetes
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Correlation between aldosterone/renin ratio before administration of eplerenone and anti-hypetensive effect.
- Secondary Outcome Measures
Name Time Method Correlation between other parameters, which include BMI, waist circumference, gender, urinary Na excretion, urinary aldosterone, urinary free cortisol, renal 11beta-hydroxysteroid dehydrogenase activity, serum K, creatinine, ANP, BNP, and urinary 8OHdG, and anti-hypetensive effect.