Treatment of Progressive Multiple Sclerosis-related Cognitive Impairment, Fatigue, and Depression Using Repetitive Transcranial Magnetic Stimulatio
- Conditions
- Nervous System Diseases
- Registration Number
- PACTR202403516079512
- Lead Sponsor
- Science Technology and Innovation Funding Authority
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 60
Definite MS patients according to 2017 revisions of the McDonald criteria.
-Progressive types of MS: Patient must fulfill diagnostic criteria of either: Secondary progressive MS (SPMS) or Primary progressive MS (PPMS)
-Free of clinical relapses for at least 3 months prior to inclusion.
-Free of steroid treatment for at least 6 weeks prior to inclusion.
-No change in their medications, whether disease modifying treatment or symptomatic therapy for at least 3 months if applicable.
-EDSS score below 6 points and stable over the past 3 months.
-A score of <34 on Symbol Digit Modalities Test, a score of = 12 on the Beck Depression Inventory (Beck et al., 1961), a score of = 38 on the Modified Fatigue Impact Scale.
-Level of education: at least can read and write.
-Written informed consent from the participants
-Conditions that could affect the participants’ level of cognition, fatigue, or depression, including; pregnancy, history of substance use disorder, history of significant neurological disorder other than MS, psychiatric, endocrinological, hepatic, renal, collagen, or other systemic comorbidities that could affect these symptoms.
-Contraindication to TMS: history of seizures, skull bone defects, metal fragments in the head, implanted metallic devices such as cardiac pacemakers, cochlear implants, medical pumps…, etc.
-Illiterate patients.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method