NCT05733026招募中不适用
Effect of Genetic and Epigenetic Factors on the Clinical Response and Toxicity to Doxorubicin Among Egyptian Breast Cancer Patients
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Cardiotoxicity
研究概览
简要总结
Recent advances in technologies, such as microarray and high-throughput sequencing, represented a deeper understanding of molecular biology, especially noncoding RNA (ncRNA). It was found that there are only <2 % of the total genome sequence as protein-coding genes while at least 98 % of the genome are transcribed into ncRNA. In the past, non-protein-coding RNAs were known as "transcription noise," but now it is obvious that ncRNAs play a crucial regulatory role in cell differentiation and organism growth and metabolism.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Metastatic and localized breast cancer patients treated with Doxorubicin among chemotherapeutic protocol.
- •Measurable disease.
- •Age of 18 years to 80 years.
- •The women of childbearing age must use an effective contraception for the duration of the study.
排除标准
- •Breast cancer patients who had undergone radiotherapy or chemotherapy.
- •Pregnant and lactating females.
- •History of allergic reactions attributed to compounds of similar chemical or biologic composition to chemotherapeutic agents used.
- •Any other medical or psychiatric condition or severe or chronic laboratory abnormality making the inclusion of the patient in the study inappropriate in the opinion of the investigator.
结局指标
主要结局
Cardiotoxicity
时间窗: 6 months
Occurrence of dilated cardiomyopathy
次要结局
- Nephrotoxicity(6 months)
研究者
Neven Sarhan
Lecturer
Misr International University
研究点 (1)
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