Effects of Fish-oil on Mood and Cognitive Functions of Healthy Individuals
- Conditions
- Depression
- Registration Number
- NCT01104194
- Lead Sponsor
- Leiden University Medical Center
- Brief Summary
The investigators recently found a positive effect of omega-3 supplements on cognitive function in healthy individuals after 4 weeks (J of Psychopharmacology 2009, 23: 831-840). The investigators hypothesize that 4 weeks consumption of omega-3 supplements in previously depressed individuals will positively affect their cognitive functions.
Secondly, low Heart Rate Variability (HRV) is a risk factor for cardiovascular disease. Some studies have found low HRV in patients with depression. No studies have investigated the effects of omega-3 fatty acid supplements on Heart Rate Variability in individuals with a history of depression. The investigators will test the hypotheses that omega-3 supplements lead to an improvement of heart rate variability indices in healthy volunteers with a history of depression.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
- Dutch-speaking men and women
- Normal weight (BMI between 18 and 27).
- Regular diets, not containing fish more than once a week.
- History of depression (at least one major depressive episode in the past).
- Currently more than mildly depressed (BDI-II-NL score higher than 19, or score on the suicidality item of this scale higher than 1).
- Current or past psychosis
- Current substance abuse or past substance dependence
- Smoking or current use of soft drugs (current = month prior to study till completion)
- Any hard drug use (lifetime)
- More than 3 alcoholic consumptions/day
Participants will be asked to keep their dietary habits constant throughout the study.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Cognition 4 weeks Battery of test measuring emotional and neutral information processing. Largest effect expected on Decision Making Test (cf. Antypa et al., 2009) and Emotion Recognition Test.
Heart Rate Variability 4 weeks
- Secondary Outcome Measures
Name Time Method Mood states 4 weeks Fatigue, Anger, Tension, Anxiety, Vigor (Profile of Mood States, self-report measure).
Depressive symptoms.
Related Research Topics
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Trial Locations
- Locations (1)
Leiden University
🇳🇱Leiden, ZH, Netherlands
Leiden University🇳🇱Leiden, ZH, Netherlands