ISRCTN74038076CompletedNot Applicable
Sequential maintenance immunosuppression with mycophenolate and prednisolone: a randomised interventional trial in progressive immunoglobulin A nephritis (IgAN)
niversitätsklinikum Ulm (Germany)0 sites70 target enrollmentStarted: May 12, 2008Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 70
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Sex
- All
Inclusion Criteria
- •1. Mesangioproliferative IgA glomerulonephritis in kidney biopsy
- •2. Steadily progressive type IgAN = loss of renal function of 2 to 3 ml/min per month before immunosuppressive induction therapy
- •3. Completion of any form of an immunosuppressive induction protocol (Pozzi, Ballardie, Rasche, experimental)
- •4. Still impaired renal function after induction therapy with a glomerular filtration rate (GFR) less than 60 ml/min
- •5. Aged between 18 and 68 years, either sex
Exclusion Criteria
- •1. Secondary forms of IgAN e.g. anti-nuclear antibody positive (ANA+) lupus, anti-neutrophil cytoplasmic antibody positive (ANCA+) vasculitis, human immunodeficiency virus (HIV), liver cirrhosis
- •2. Rapidly progressive type three IgAN with crescents in greater than or equal to 30% of glomeruli
- •3. Serum creatinine less than 130 mcmol/l or greater than 400 mcmol/l after induction therapy
Investigators
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