Pharmacokinetics and safty of KRP-AM1977Y in healthy adult volunteers

The plasma concentration trough values of AM-1977 and AM2012-008 when KRP-AM1977Y 150mg (300mg on the first day) was administered for 7 days ranged from 0.771 to 0.915 and 0.0789 to 0.0887ug/mL, respectively. On day 7, Cmax of AM-1977 and AM2012-008 was 2.92, 0.124ug/mL and AUC was 35.4, 2.48ug*h/mL, respectively. The urinary excretion rates of AM-1977 and AM2012-008 were 17.5%, 27.4%. No clinically significant safety finding was reported.