Measurement of yellow fever vaccine efficacy; is 10 years the right point in time for revaccination?
Completed
- Conditions
- Yellow fever infection10047438
- Registration Number
- NL-OMON39667
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 119
Inclusion Criteria
> 18 years
having been administered a yellow fever vaccination
Exclusion Criteria
< 18 Years
Vaccination administered < 10 years prior
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary outcome measure is the proportion of volunteers who have 0.7 log10<br /><br>plaque<br /><br>reduction, as challenge experiments have shown this to correlate with<br /><br>protection.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Another outcome measure is the proportion of volunteers who have YF-17D-specific<br /><br>memory, as shown by the presence of YF-17D-specific cytokine producing CD8+ and<br /><br>CD4+ T cells.</p><br>